How does Coumadin / Warfarin Sodium work ?
Mechanism of Action
Warfarin is exposed to interfere with clotting factor synthesis by
inhibition of Vitamin k dependant clotting factor, thereby reducing the
regeneration of vitamin K1 epoxide. The degree of suppression is
dependent upon the dosage given. Therapeutic doses of Warfarin
decrease the total amount of the active form of each vitamin K
dependent clotting factor made by the liver. This treatment was
developed by Bristol Myers Squibb. Approved by the FDA, Warfarin Sodium
has since then become famous.
Side Effects of Warfarin sodium
Warfarin or its generic alternatives all have certain side effects, the
most common of which are fatal or non fatal hemorrhage from any organ.
This is because of cascade of anticoagulant. The signs, symptoms and
severity of same may vary as location or extent of bleeding. The other
side effects may be noted such as paresthesia, headache, chest,
abdomen, joint, muscle or other pain, dizziness, shortness of breath or
swallowing; unexplained swelling; weakness; low pressure. Necrosis or
gangrene of skin tissue is also a side effect reported. Therefore, the
possibility of hemorrhage should be considered in evaluating the
condition of any patient who has been treated with anti-coagulants. The
severity of these Warfarin Sodium side effects depends on the dosage
taken. Warfarin Sodium is a regular on going medication; so you take it
on a very much regular dosage. Moreover, it is meant to be used only by
the prescription of a doctor; it should be used with cautions in
special populations like children, pregnant females.
Guidelines before taking Coumadin
Certain precautions should be taken prior to taking Warfarin. The most
important is that it should only be taken under medical supervision.
Benefit of Warfarin treatment should be considered with the side effect
of hemorrhage. Warfarin therapy should be discontinued when Warfarin
is suspected to be the cause of developing necrosis. Warfarin can be
taken with or without food at anytime or as prescribed by your
physician. Diet control should be exercised, especially with regard to
foods containing high concentration of vitamin K. If you are having
hypersensitivity towards Warfarin sodium or any other bleeding problem
then you should consult your doctor clarifying the condition. If you
are using alcohol then you should avoid taking Warfarin as it affects
dosage.
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