DRUG INTERACTIONS: Combining valsartan with potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to hyperkalemia (elevated potassium in the blood) and in heart failure patients, it increases serum creatinine, a test used for monitoring function of the kidneys.
PREGNANCY: When used in the second or third trimester of pregnancy , valsartan and similar drugs can cause injury and even death to the fetus. Valsartan should not be used during pregnancy. When pregnancy is detected, valsartan should be stopped as soon as possible.
NURSING MOTHERS: It is not known whether valsartan is secreted into human milk. Valsartan is secreted into the milk of rats.
SIDE EFFECTS: Valsartan is generally well-tolerated and side effects are rare. The most common side effects include headache, dizziness, fatigue , abdominal pain, cough, diarrhea and nausea. Patients may also experience hyperkalemia, impotence, reduced renal function, and allergic reactions. Rhabdomyolysis (inflammation and destruction of muscles) and angioedema (swelling of soft tissues including those of the throat and larynx) are rare but serious side effects of valsartan.
DRUG INTERACTIONS: Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: digoxin, lithium, certain non-steroidal anti-inflammatory drugs (e.g., indomethacin), potassium-sparing "water pills" (diuretics such as amiloride, spironolactone, triamterene), "water pills" (diuretics such as furosemide), potassium supplements (e.g., potassium chloride) or salt substitutes. Check the labels on all your medicines (e.g., cough-and-cold products, diet aids) because they may contain ingredients that could increase your heart rate or blood pressure. Ask your pharmacist about the safe use of those products. Do not start or stop any medicine without doctor or pharmacist approval.
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