People with diabetes mellitus have a deficiency or absence of a hormone produced by the pancreas called insulin. Insulin is the main hormone responsible for the control of sugar in the blood. In type 2 diabetes the pancreas does not produce sufficient insulin and the cells of the body are resistant to the low levels of insulin circulating in the blood. Insulin would normally make the cells remove sugar from the blood, hence in type 2 diabetes blood sugar levels can rise too high.
Avandamet tablets contain two active ingredients, rosiglitazone
maleate and metformin hydrochloride. These are both medicines that are used to
help control blood sugar levels in people with type 2 or non-insulin dependent
diabetes.
Rosiglitazone is a type of antidiabetic medicine known
as a thiazolidinedione or glitazone. It helps to control blood sugar levels by
increasing the sensitivity of liver, fat and muscle cells to insulin. This
enables these cells to remove sugar from the blood more effectively.
Rosiglitazone also preserves the functioning of the cells in the pancreas (beta
cells) that produce insulin.
Metformin is a type of antidiabetic medicine known
as a biguanide. It works in a number of ways to decrease the amount of sugar in
the blood. Firstly, it reduces the amount of sugar produced by cells in the
liver. Secondly, it increases the sensitivity of muscle cells to insulin. This
enables these cells to remove sugar from the blood more effectively. Finally,
it also delays absorption of sugar from the intestines into the bloodstream
after eating.
This combination of medicines helps people with type 2 diabetes
control their blood sugar levels both directly after meals and between meals.
Possible Side Effects
Sore throat, muscle pain, or tooth problems may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Tell your doctor immediately if any of these unlikely but serious side effects occur: swelling, unexplained rapid weight gain, trouble breathing, unusual fatigue, fast, pounding heartbeat, changes in menstrual cycles. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: dark urine, yellowing of eyes, skin, persistent nausea, vomiting, stomach, abdominal pain.
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